関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Eth-1-ynyl-4-(pentyloxy)benzene | HCID 2775119 | — |
| 反応物 | alpha-Chloro-4-methoxycarbonylbenzaldoxime | HCID 73989494 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Methyl 4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)benzoate | HCID 10737571 | 84.6% |
反応手順
To a solution of 4-Methoxycarbonylphenylhydroxyiminomethyl chloride (16.98 g) and 4-n-pentyloxyphenylacetylene (18.96 g) in tetrahydrofuran (170 ml) was added triethylamine (14.4 ml) in tetrahydrofuran (140 ml) over a period of 2 hours at 40° C. and the mixture was stirred at 40° C. for 30 minutes. The mixture was diluted with dichloromethane and washed with water and brine. The separated organic layer was dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with acetonitrile. The precipitate was collected by filtration and dried to give Methyl 4-[5-(4-n-pentyloxyphenyl)isoxazol-3-yl]benzoate (24.56 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06107458 |
|---|
| 出典データセット | uspto-grants-2000_08 |
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| ORD ID | ord-b78335e158dd48b8bd5da9f7ec3aed03 |
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| 出典メモ | uspto-grants-2000_08 |
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