Hydrochloric Acid → 4-[4-[8-(2,6-Dimethylmorpholin-4-yl)octyloxy]phenyl]benzoic acid hydrochloride

HRID 1872406ノート

反応式

HRID 1872406 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]2[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)=[CH:13][CH:12]=1.O.C(OCC)(=O)C.[ClH:33].[CH3:34][CH:35]1[O:40][CH:39]([CH3:41])[CH2:38][NH:37][CH2:36]1>>[ClH:33].[CH3:41][CH:39]1[O:40][CH:35]([CH3:34])[CH2:36][N:37]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[CH:25]=[CH:24][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=3)=[CH:13][CH:12]=2)[CH2:38]1

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 8857Ethyl AcetateHCID 1108622,6-DimethylmorpholineHCID 211822604-[4-(8-Bromooctyloxy)phenyl]benzoic acid

生成物 1

HCID 700603274-[4-[8-(2,6-Dimethylmorpholin-4-yl)octyloxy]phenyl]benzoic acid hydrochloride

実験手順

A suspension of 4-[4-(8-bromooctyloxy)phenyl]benzoic acid (1 g) in 2,6-dimethylmorpholine (3.06 ml) was refluxed for 30 minutes. The reaction mixture was added to a mixture of water and ethyl acetate and adjusted to pH 2.0 with conc. HCl. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 4-[4-[8-(2,6-dimethylmorpholin-4-yl)octyloxy]phenyl]benzoic acid hydrochloride (0.95 g).

後処理

  1. temperaturewas refluxed for 30 minutes
  2. dry with materialdried over magnesium sulfate
  3. filtrationThe magnesium sulfate was filtered off
  4. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3a36a55a48764fb5a68f546f39383296
出典データセット
uspto-grants-2000_08
特許番号
US06107458

反応ノート

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