5-Aminoisoquinoline → 5-Amino-1,2,3,4-tetrahydroisoquinoline

HRID 1872692ノート

反応式

HRID 1872692 の反応式
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2>C(O)(=O)C.S(=O)(=O)(O)O.[Pt]=O>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

参加物

5

反応物 1

HCID 707665-Aminoisoquinoline

生成物 1

HCID 162174995-Amino-1,2,3,4-tetrahydroisoquinoline収率 63.1%

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 176Acetic Acid溶媒HCID 1118Sulfuric Acid溶媒

実験手順

A solution of 5-aminoisoquinoline (10 g, 69 mmol) in glacial acetic acid (150 ml) and concentrated sulfuric acid (1 ml) was hydrogenated over platinum oxide (1 g) at 55 psi for 20h. The acetic acid was then removed in vacuo and the residue treated with saturated aqueous potassium carbonate (100 ml) and extracted with dichloromethane. The organic layer was dried over sodium sulfate and concentrated in vacuo to afford the title compound (6.45 g).

後処理

  1. customThe acetic acid was then removed in vacuo
  2. additionthe residue treated with saturated aqueous potassium carbonate (100 ml)
  3. extractionextracted with dichloromethane
  4. dry with materialThe organic layer was dried over sodium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5a34c24bdfef4d0aaf46bd3e42941566
出典データセット
uspto-grants-2000_08
特許番号
US06110934

反応ノート

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