Morpholine, 4-chloro- → 4-n-Butyl-2-methoxy-5 chlorobenzoic acid

反応式

[CH2:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([O:14][CH3:15])[CH:6]=1)[CH2:2][CH2:3][CH3:4].[Cl:16]N1CCOCC1>>[CH2:1]([C:5]1[C:13]([Cl:16])=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[C:7]([O:14][CH3:15])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

参加物

反応物 2

HCID 90067Morpholine, 4-chloro-

HCID 186873724-n-Butyl-2-methoxybenzoic acid

生成物 1

HCID 186874174-n-Butyl-2-methoxy-5 chlorobenzoic acid

実験手順

4-n-Butyl-2-methoxybenzoic acid (0.5 g; 2.9 mmol) and N-chloromorpholine (356 mg; 2.9 mmol) were treated in a similar manner to that described in Preparation 24 to give the title compound as a white soid (0.4 g).

後処理

customdescribed in Preparation 24

出典と根拠

ORDレコード: ord-f73aa7e27772481e9fa24b9935f4ecaa
出典データセット: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06110934

反応ノート

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