Water → 4-Ethylbenzo[d]oxazol-5-amine

HRID 1872785ノート

反応式

HRID 1872785 の反応式
[CH2:1]([C:3]1[C:8]2[N:9]=[CH:10][O:11][C:7]=2[CH:6]=[CH:5][C:4]=1[NH:12]C(=O)C(F)(F)F)[CH3:2].O.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>CO>[NH2:12][C:4]1[CH:5]=[CH:6][C:7]2[O:11][CH:10]=[N:9][C:8]=2[C:3]=1[CH2:1][CH3:2]

参加物

6

反応物 4

HCID 962Water2 回HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 154801414-Ethyl-5-trifluoroacetamidobenzoxazole

生成物 1

HCID 154801424-Ethylbenzo[d]oxazol-5-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
90 °C

実験手順

A solution of 4-ethyl-5-trifluoroacetamidobenzoxazole (14.13 mmol) in a 20% mixture of water in methanol (20 mL) is treated with anhydrous potassium carbonate (56.52 mmol). A reflux condenser is attached and the mixture is heated to 90° C. with an oil bath for five hours. The mixture is cooled to room temperature and distributed between ethyl acetate (100 mL) and water (100 mL). The ethyl acetate layer is dried over magnesium sulfate and concentrated under reduced pressure to yield a black residue. This material is purified by chromatography (silica gel, 50% ethyl acetate/hexanes) to afford 5-amino-4-ethylbenzoxazole.

後処理

  1. customA reflux condenser is attached
  2. temperatureThe mixture is cooled to room temperature
  3. dry with materialThe ethyl acetate layer is dried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customto yield a black residue
  6. customThis material is purified by chromatography (silica gel, 50% ethyl acetate/hexanes)

出典と根拠

ORDレコード
ord-dd41e73abcee457db3f9e19b0346cdc1
出典データセット
uspto-grants-2000_08
特許番号
US06110952

反応ノート

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