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HRID 1872833作成日：2026年10月27日

4-(5-Fluoro-1H-indol-3-YL)cyclohexanone → 3-(4-oxocyclohexyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1872833

反応式

関与物質

役割名称HCID仕込み量
反応物4-(5-Fluoro-1H-indol-3-YL)cyclohexanoneHCID 10704683—
反応物3-(1,4-Dioxa-spiro[4,5]dec-8-yl)-5-cyano-1H-indoleHCID 15521973—
生成物3-(4-oxocyclohexyl)-1H-indole-5-carbonitrileHCID 11241886—

反応手順

This compound was prepared in the manner as described above for (3a) by replacing 4-(5-fluoro-1H-3-indolyl)-cyclohexanone ethylene ketal with 4-(5-cyano-1H-3-indolyl)-cyclohexanone ethylene ketal (6 g) in 81% (4.0 g) of product as a white solid: mp 162.5-164° C.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US06110956
出典データセットuspto-grants-2000_08
ORD IDord-2d2af9a4a22843a7bbacec252f6804c3
出典メモuspto-grants-2000_08