Hydrochloric Acid → HCID 68569999、化合物

HRID 18730

反応式

HRID 18730 の反応式
[ClH:1].C(OC([N:9]1[C@H:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@H:12]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[N:11]=[C:10]1[N:26]([CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:27])=O)(C)(C)C>CCOC(C)=O>[ClH:1].[C:14]1([C@H:13]2[C@@H:12]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:11][C:10]([N:26]([CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH3:27])=[N:9]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 685697692-(N-Methylbenzylamino)-cis-4,5-diphenyl-4,5-dihydro-imidazole-1-carboxylic Acid Tert-Butyl Ester

生成物 1

HCID 68569999HCID 68569999、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

Hydrogen chloride is bubbled into a solution of 81 (110 mg, 0.25 mmol) in EtOAc (10 mL) for 1 min, and the solution is stirred at RT for 6 h. The solvent is removed by rotary evaporation, and the residue triturated with Et2O. The insoluble material is dissolved in dichloromethane and Et2O is added, and the precipitate is filtered to give 43 mg of the product 82. 1H NMR (DMSO-d6) δ 9.28 (s, 2 H), 7.60-7.30 (m, 5 H), 7.25-6.95 (m, 10 H), 5.58 (s, 2 H), 4.78 (s, 2 H), 3.15 (s, 3 H); MS: m/z 342 (M++1).

後処理

  1. customThe solvent is removed by rotary evaporation
  2. customthe residue triturated with Et2O
  3. dissolutionThe insoluble material is dissolved in dichloromethane
  4. additionEt2O is added
  5. filtrationthe precipitate is filtered

出典と根拠

ORDレコード
ord-8b78430b99e84b96823c30cf25d16894
出典データセット
uspto-grants-2010_06
特許番号
US07741493B2

関連ノート

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