Ammonium Hydroxide → 2-Chloro-4-methylpyridine-3-carboxamide
反応式
[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH3:10])[CH:5]=[CH:4][N:3]=1.[OH-:11].[NH4+]>OS(O)(=O)=O>[Cl:1][C:2]1[C:7]([C:8]([NH2:9])=[O:11])=[C:6]([CH3:10])[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
A solution of 6.33 g of 2-chloro-4-methyl-3-pyridine carbonitrile (9) in 6 mL concentrated H2SO4 was stirred at 100° C. for one hour, added ice water, made alkaline with ammonium hydroxide and extracted with ethyl acetate. The extract was dried and the solvent removed to leave a crystalline residue. Recrystallization from ethyl acetate gave 4.9 g (69%) of (10).
後処理
- extractionextracted with ethyl acetate
- customThe extract was dried
- customthe solvent removed
- customto leave a crystalline residue
- customRecrystallization from ethyl acetate
出典と根拠
- ORDレコード
- ord-6ff931a77aef49049696122b83f1db21
- 出典データセット
- uspto-grants-2000_08
- 特許番号
- US06111112
反応ノート
読み込み中…