Sodium Bicarbonate → HCID 178455311、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Sodium Bicarbonate	HCID 516892	—
反応物	Hydrogen chloride dimer	HCID 6410751	—
反応物	2-Amino-4-(4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-6-mercaptopyridine-3,5-dicarbonitrile	HCID 178455031	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	HCID 178455311	HCID 178455311	—

反応手順

97 mg (0.23 mmol) of the compound from Example 12A (cis isomer), 46 mg (0.28 mmol) of 3-pyridinemethyl chloride hydrochloride and 78 mg (0.93 mmol) of sodium bicarbonate are initially charged in 2 ml of dry DMF and stirred at RT for 20 h. The mixture is then filtered and the filtrate is directly purified by preparative HPLC (column: YMC GEL ODS-AQ S-5/15 μm; mobile phase gradient: acetonitrile/water 10:90→95:5).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08304412B2
出典データセット	uspto-grants-2012_11
ORD ID	ord-d4aef8cd923d4cbea1d0936d25f682a3
出典メモ	uspto-grants-2012_11