Sodium Sulfide → HCID 178433544、化合物
反応式
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][O:11]2)[C:5]([C:16]#[N:17])=[C:4]([CH3:18])[N:3]=1.[S-2:19].[Na+].[Na+]>CN(C=O)C>[CH3:18][C:4]1[C:5]([C:16]#[N:17])=[C:6]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][O:11]2)[C:7]([C:8]#[N:9])=[C:2]([SH:19])[N:3]=1参加物
4
実験手順
471 mg (1.35 mmol) of the compound from Example 40A are initially charged in 4 ml of dry DMF, and 126 mg (1.62 mmol) of sodium sulfide are added. The reaction mixture is stirred at RT for 12 h. The solvent is then removed on a rotary evaporator and the residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 200:1→5:1).
後処理
- customThe solvent is then removed on a rotary evaporator
- customthe residue is purified chromatographically on silica gel 60 (mobile phase: gradient dichloromethane/ethanol 200:1→5:1)
出典と根拠
- ORDレコード
- ord-b3dc74507d3440e58c399b5a6527ceae
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08304412B2
反応ノート
読み込み中…