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Diisopropylamine → 3-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-N,N-diisopropyl-acrylamide

HRID 1873772
ノート
印刷プレビュー

反応式

HRID 1873772 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH:13]=[CH:14][C:15]([OH:17])=O)[S:11][CH:12]=2)=[CH:4][CH:3]=1.[CH:18]([NH:21][CH:22]([CH3:24])[CH3:23])([CH3:20])[CH3:19].C(N(CC)CC)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([CH:13]=[CH:14][C:15]([N:21]([CH:22]([CH3:24])[CH3:23])[CH:18]([CH3:20])[CH3:19])=[O:17])[S:11][CH:12]=2)=[CH:6][CH:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 7912DiisopropylamineHCID 8471TriethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 687134823-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-acrylic Acid

生成物 1

HCID 687106003-[4-(4-Fluoro-phenyl)-thiazol-2-yl]-N,N-diisopropyl-acrylamide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

98 mg (0.39 mmol) of 3-[4-(4-fluoro-phenyl)-thiazol-2-yl]-acrylic acid, 79.6 mg (0.78 mmol) of diisopropylamine, 119.35 mg (1.17 mmol) of triethylamine and 164.5 mg (0.43 mmol) of HATU in 5 ml of DMF were stirred at room temperature for 2 h. The reaction mixture was concentrated, and water and ethyl acetate were added. The organic phase was separated, washed and evaporated. The residue was purified by chromatography (RP18). Yield: 39 mg.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionwater and ethyl acetate were added
  3. customThe organic phase was separated
  4. washwashed
  5. customevaporated
  6. customThe residue was purified by chromatography (RP18)

出典と根拠

ORDレコード
ord-8da3d2a4f8374f5cad5dfc9b6a610118
出典データセット
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08304438B2

反応ノート

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