2-Nitro-5-(3-nitrophenoxy)pyridine → 5-(3-Aminophenoxy)pyridin-2-amine

HRID 1874321ノート

反応式

HRID 1874321 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-])=O)[CH:12]=2)=[CH:6][N:5]=1)([O-])=O>CO.[C].[Pd]>[NH2:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[O:10][C:7]1[CH:8]=[CH:9][C:4]([NH2:1])=[N:5][CH:6]=1

参加物

4

反応物 1

HCID 577491152-Nitro-5-(3-nitrophenoxy)pyridine

生成物 1

HCID 577491665-(3-Aminophenoxy)pyridin-2-amine収率 96.1%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To a solution of 2-nitro-5-(3-nitrophenoxy)pyridine (1.33 g, 5.07 mmol) in methanol (10 mL) was added palladium carbon (50% water-containing product, 100 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 12 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure and dried to give the title compound (980 mg, 96%) as a yellow oil.

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customdried

出典と根拠

ORDレコード
ord-a81113a96572486e82148948405ef910
出典データセット
uspto-grants-2012_11
特許番号
US08304557B2

反応ノート

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