反応式
[CH3:1][N:2]1[C:6]([C:7]([NH:9][C:10]2[CH:15]=[C:14]([O:16][C:17]3[CH:18]=[N:19][C:20]([N+:23]([O-])=O)=[CH:21][CH:22]=3)[CH:13]=[CH:12][C:11]=2[CH3:26])=[O:8])=[CH:5][C:4]([CH3:27])=[N:3]1>CO.[C].[Pd]>[NH2:23][C:20]1[N:19]=[CH:18][C:17]([O:16][C:14]2[CH:13]=[CH:12][C:11]([CH3:26])=[C:10]([NH:9][C:7]([C:6]3[N:2]([CH3:1])[N:3]=[C:4]([CH3:27])[CH:5]=3)=[O:8])[CH:15]=2)=[CH:22][CH:21]=1参加物
4
実験手順
To a solution of 1,3-dimethyl-N-{2-methyl-5-[(6-nitropyridin-3-yl)oxy]phenyl}-1H-pyrazole-5-carboxamide (3.38 g, 9.20 mmol) in methanol (20 mL) was added palladium carbon (50% water-containing product, 300 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 4 hr. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was collected by filtration and washed with ethyl acetate-hexane to give the title compound (2.94 g, 95%) as a white solid.
後処理
- filtrationThe reaction mixture was filtered through celite
- concentrationthe filtrate was concentrated under reduced pressure
- filtrationThe residue was collected by filtration
- washwashed with ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-483ad65a89a841d0961d5d17a785dd2b
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08304557B2
関連ノート
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