化工社化工社 化学情報印刷レポート · 研究参考用
Cyclopropanecarbonyl chloride → N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-5-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopropanecarbonyl chloride | HCID 77637 | — |
| 反応物 | N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide | HCID 57749338 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-5-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide | HCID 57749346 | 53% |
反応手順
In the same manner as in Example 28-2 and using N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide (303 mg, 0.803 mmol), cyclopropanecarbonyl chloride (74.0 μL, 0.815 mmol) and N,N-dimethylacetamide (10 mL) as starting materials, the title compound (188 mg, 53%) was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08304557B2 |
| 出典データセット | uspto-grants-2012_11 |
| ORD ID | ord-aebf4e57c2974938bfea9f35beeec54d |
| 出典メモ | uspto-grants-2012_11 |