2,5-Dimethyl-3-furoyl Chloride → HCID 57749165、化合物
反応式
[CH3:1][C:2]1[O:3][C:4]([CH3:10])=[CH:5][C:6]=1[C:7](Cl)=[O:8].[NH2:11][C:12]1[CH:13]=[C:14]([CH:31]=[CH:32][C:33]=1[CH3:34])[O:15][C:16]1[CH:17]=[CH:18][C:19]2[N:20]([N:22]=[C:23]([NH:25][C:26]([CH:28]3[CH2:30][CH2:29]3)=[O:27])[N:24]=2)[CH:21]=1>CN(C)C(=O)C>[CH:28]1([C:26]([NH:25][C:23]2[N:24]=[C:19]3[CH:18]=[CH:17][C:16]([O:15][C:14]4[CH:31]=[CH:32][C:33]([CH3:34])=[C:12]([NH:11][C:7]([C:6]5[CH:5]=[C:4]([CH3:10])[O:3][C:2]=5[CH3:1])=[O:8])[CH:13]=4)=[CH:21][N:20]3[N:22]=2)=[O:27])[CH2:29][CH2:30]1参加物
4
実験手順
In the same manner as in Example 58 and using 2,5-dimethyl-3-furoyl chloride (84.0 μL, 0.630 mmol), N,N-dimethylacetamide (5 mL) and N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (185 mg, 0.572 mmol) as starting materials, the title compound (150 mg, 56%) was obtained as a white solid.