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Cyclobutanecarbonyl chloride → N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]cyclobutanecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclobutanecarbonyl chloride | HCID 78705 | — |
| 反応物 | N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | HCID 57749401 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]cyclobutanecarboxamide | HCID 57749178 | 47.6% |
反応手順
In the same manner as in Example 24 and using cyclobutanecarbonyl chloride (56.0 μL, 0.489 mmol), N,N-dimethylacetamide (5 mL) and N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (140 mg, 0.433 mmol) as starting materials, the title compound (83.5 mg, 45%) was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08304557B2 |
| 出典データセット | uspto-grants-2012_11 |
| ORD ID | ord-ebfbefb222d74d29a7cd24f82e9a44ce |
| 出典メモ | uspto-grants-2012_11 |