化工社化工社 化学情報印刷レポート · 研究参考用
Tetrahydrofuran → N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2,5-dimethyl-1,3-oxazole-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 2,5-Dimethyl-1,3-oxazole-4-carboxylic acid | HCID 2795465 | — |
| 反応物 | N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | HCID 57749401 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | N-[5-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-2-methylphenyl]-2,5-dimethyl-1,3-oxazole-4-carboxamide | HCID 57749120 | 83.1% |
反応手順
In the same manner as in Example 55 and using 2,5-dimethyl-1,3-oxazole-4-carboxylic acid (65.0 mg, 0.462 mmol), tetrahydrofuran (5 mL), thionyl chloride (77.0 μL, 0.888 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (129 mg, 0.399 mmol) and N,N-dimethylacetamide (6 mL) as starting materials, the title compound (148 mg, 83%) was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08304557B2 |
| 出典データセット | uspto-grants-2012_11 |
| ORD ID | ord-196d45c95f2741a8aa25763dd55e2f97 |
| 出典メモ | uspto-grants-2012_11 |