Acetyl chloride → N-(3-{[2-(acetylamino)[1,3]thiazolo[5,4-b]pyridin-5-yl]oxy}phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide

HRID 1874515

反応式

HRID 1874515 の反応式
[NH2:1][C:2]1[S:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[C:6]([O:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[C:23]([CH3:27])[CH:22]=3)=[O:20])[CH:15]=[CH:16][CH:17]=1)[N:5]=2.[C:28](Cl)(=[O:30])[CH3:29]>CN(C)C(=O)C>[C:28]([NH:1][C:2]1[S:3][C:4]2[C:9]([N:10]=1)=[CH:8][CH:7]=[C:6]([O:11][C:12]1[CH:13]=[C:14]([NH:18][C:19]([C:21]3[N:25]([CH3:26])[N:24]=[C:23]([CH3:27])[CH:22]=3)=[O:20])[CH:15]=[CH:16][CH:17]=1)[N:5]=2)(=[O:30])[CH3:29]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 57749158N-{3-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

生成物 1

HCID 57749323N-(3-{[2-(acetylamino)[1,3]thiazolo[5,4-b]pyridin-5-yl]oxy}phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide収率 57%

試薬・触媒・溶媒 1

HCID 31374Dimethylacetamide溶媒

実験手順

In the same manner as in Example 28-2 and using N-{3-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]phenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide (199 mg, 0.523 mmol), N,N-dimethylacetamide (2 mL) and acetyl chloride (89.2 μL, 1.26 mmol) as starting materials, the title compound (125 mg, 57%) was obtained as a white solid.

出典と根拠

ORDレコード
ord-c1ad646c09b542f2a4f9fbfa68bd4324
出典データセット
uspto-grants-2012_11
特許番号
US08304557B2

関連ノート

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