Triethylamine → 5-[bis(Cyclopropylmethyl)amino]-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide

Triethylamine (0.049 mL, 0.355 mmol) was added to a suspension of 5-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate (0.207 g, 0.355 mmol) in dichloroethane (5 mL). To the resulting solution was added cyclopropanecarbaldehyde (0.027 mL, 0.355 mmol) and sodium triacetoxyborohydride (0.188 g, 0.887 mmol). After stirring at RT overnight, the reaction mixture was diluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate. The organic layer was dried over sodium sulfate and concentrated. The residue was purified by column chromatography (dichloromethane/methanol) to give the title compound (0.075 g, 37%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ ppm 11.23 (d, 1H), 8.89 (t, 1H), 7.80 (d, 1H), 7.43-7.55 (m, 3H), 7.33-7.41 (m, 1H), 7.24 (d, 1H), 6.86-7.00 (m, 3H), 4.54 (d, 2H), 3.16 (d, 4H), 0.75-1.05 (m, 2H), 0.21-0.57 (m, 4H), −0.05-0.26 (m, 4H). MS: m/z 577 (M+1).

1. washwashed with saturated aqueous sodium bicarbonate
2. dry with materialThe organic layer was dried over sodium sulfate
3. concentrationconcentrated
4. customThe residue was purified by column chromatography (dichloromethane/methanol)

ORDレコード

ord-41c73b94fd72403e97071740de14e22f

出典データセット

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08304419B2