1,2-Dichloroethane → HCID 178509916、化合物

A solution of 3-{[3-(aminomethyl)-6-(difluoromethyl)-2-fluorophenyl]oxy}-5-chlorobenzonitrile (0.08 g, 0.245 mmol), 2-azido-4-chloro-1H-imidazole-5-carboxylic acid (0.046 g, 0.245 mmol), EDC (0.047 g, 0.245 mmol) and HOBT (0.037 g, 0.245 mmol) in N,N-Dimethylformamide (DMF) (4 ml) were stirred at RT under an atmosphere of nitrogen for 16 h then ethyl acetate (30 mL) and saturated aqueous NaHCO3 solution (30 mL) were added. The organic layer was separated, washed with saturated aqueous NaHCO3 solution (30 mL), water (30 mL), brine (30 mL), dried over MgSO4, filtered and concentrated. A mixture of 2-azido-5-chloro-N-{[3-[(3-chloro-5-cyanophenyl)oxy]-4-(difluoromethyl)-2-fluorophenyl]methyl}-1H-imidazole-4-carboxamide (0.12 g, 0.242 mmol) and Lindlar Catalyst (5.15 mg, 0.048 mmol) in ethyl acetate (10 ml) was stirred at RT under hydrogen (55 psig) for 16 h. Next day TLC & LCMS show desired product and remaining starting material. More Lindlar Catalyst (5.15 mg, 0.048 mmol) was added and the mixture was stirred at RT under hydrogen (55 psig) for 6 h. The mixture was carefully vented, filtered thru Celite and concentrated under vacuum. The yellow solid was purified by Reverse Phase HPLC (MeCN/water+0.1 TFA) to give a white solid. The salt was stirred with ethyl acetate (15 mL) and saturated aqueous NaHCO3 solution (15 mL) for 15 min. The organic layer was separated, washed with water (15 mL), brine (15 mL), dried over MgSO4, filtered and concentrated to give 0.033 g (29%) of the title compound as a white powder. 1H NMR (400 MHz, METHANOL-d4) δ ppm 7.39-7.62 (m, 3H), 7.27 (d, 2 H), 6.92 (t, 1H), 4.66 (s, 2H). LCMS m/z 468.3 (M−H).

1. customThe organic layer was separated
2. washwashed with saturated aqueous NaHCO3 solution (30 mL), water (30 mL), brine (30 mL)
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated

ORDレコード

ord-a3800db367a745a3896cf48ace56d457

出典データセット

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08304419B2