Hydrazine → 2-Amino-4-hydroxy-6-hydrazinopyrimidine
反応式
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH2:10][NH2:11]>O>[NH2:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[C:4]([NH:10][NH2:11])[N:3]=1参加物
4
実験手順
A stirred suspension of 15.0 g (103 mmol) of 1 in 250 mL water was added 12 g (375 mmol) of anhydrous hydrazine, and the mixture was heated at reflux for 3 h. The resulting clear solution was cooled, and the precipitate which separated was collected by filtration, washed with water followed by ethanol and dried to give 6.6 g (46%) of white solid. mp decomposes at 313° C. (Literature mp 314-315° C., see Taylor, E. C.; Cocuzza, J. A. Synthesis and Properties of 7-Azaxanthopterin. J. Org. Chem. 1979, 44, 1125-1128.).
後処理
- temperaturethe mixture was heated
- temperatureat reflux for 3 h
- temperatureThe resulting clear solution was cooled
- customthe precipitate which separated
- filtrationwas collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-5d9e26ad433e4f9493543becfd1e3ab8
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08309564B2
反応ノート
読み込み中…