Dimethylamine → HCID 23144875、化合物

HRID 1875552ノート

反応式

HRID 1875552 の反応式
Br[CH2:2][C:3]1[C:4]([N+:13]([O-:15])=[O:14])=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7].[CH3:16][NH:17][CH3:18]>CO>[CH3:16][N:17]([CH2:2][C:3]1[C:4]([N+:13]([O-:15])=[O:14])=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8][CH3:9])=[O:7])[CH3:18]

参加物

4

反応物 2

HCID 674DimethylamineHCID 22509333Methyl 3-(bromomethyl)-2-nitrobenzoate

生成物 1

HCID 23144875HCID 23144875、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Methyl 3-bromomethyl-2-nitrobenzoate (1.6 g) was dissolved in methanol (5 mL). Methanol solution (6 mL) of 2M dimethylamine was added thereto and stirred overnight. After removing the solvent, the residue was diluted with 1M hydrochloric acid and washed with ethyl acetate. The water layer was alkalized with sodium hydrate aqueous solution and extracted with ethyl acetate. The usual workup procedure was conducted to obtain methyl 3-dimethylaminomethyl-2-nitrobenzoate.

後処理

  1. customAfter removing the solvent
  2. additionthe residue was diluted with 1M hydrochloric acid
  3. washwashed with ethyl acetate
  4. extractionextracted with ethyl acetate

出典と根拠

ORDレコード
ord-125cbda4b2e6404db15dc2287a577cef
出典データセット
uspto-grants-2012_11
特許番号
US08309561B2

反応ノート

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