Phosphoric Acid → (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one monophosphate
反応式
[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][C:10]1[NH:11][C:12](=[O:21])[C:13]2[C:18]([CH:19]=1)=[C:17]([CH3:20])[CH:16]=[CH:15][CH:14]=2.[P:22](=[O:26])([OH:25])([OH:24])[OH:23]>C(O)C>[P:22]([OH:26])([OH:25])([OH:24])=[O:23].[OH:1][CH2:2][C@H:3]1[CH2:7][CH2:6][CH2:5][N:4]1[CH2:8][CH2:9][C:10]1[NH:11][C:12](=[O:21])[C:13]2[C:18]([CH:19]=1)=[C:17]([CH3:20])[CH:16]=[CH:15][CH:14]=2参加物
4
実験手順
A free form (1 g) of (R)-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one was measured, ethanol (40 ml) was added and the mixture was completely dissolved by heating under reflux. Thereto was added commercially available 85% phosphoric acid (200 μL) and the mixture was left stirring at room temperature for 1 hr. The precipitate was collected by filtration and dissolved again in water (1 mL) at 80° C. Ethanol (8 mL) was added and the mixture was left standing at room temperature for 1 hr. The resulting precipitate was collected by filtration and dried under reduced pressure at 50° C. for 9 hr to give the title compound (838 mg).