2-Chlorobenzyl alcohol → 2-[2-(2-Chloro-benzyloxy)-pyridin-3-yl]-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole

HRID 1875722

反応式

HRID 1875722 の反応式
Cl[C:2]1[C:7]([C:8]2[N:12]([CH2:13][CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:11]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:10]=3[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH2:33][OH:34]>>[Cl:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=1[CH2:33][O:34][C:2]1[C:7]([C:8]2[N:12]([CH2:13][CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]3)[C:11]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:10]=3[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 288102-Chlorobenzyl alcoholHCID 86652286HCID 86652286、化合物

生成物 1

HCID 582092492-[2-(2-Chloro-benzyloxy)-pyridin-3-yl]-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole

実験手順

The title compound was prepared in analogy to Example 1, from 2-(2-chloro-pyridin-3-yl)-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole (Ex. 1, intermediate a) and (2-chloro-phenyl)-methanol (CAS Reg. No. 17849-38-6). Light yellow solid (48%). MS (Turbo Spray): m/z=468.2 (M+H).

出典と根拠

ORDレコード
ord-b8bedae4352a41788fc20455d3f13815
出典データセット
uspto-grants-2012_11
特許番号
US08309581B2

関連ノート

読み込み中…