Benzyl Bromide → 1-Benzyl-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole

反応式

[Cl:1][C:2]1[C:7]([C:8]2[NH:12][C:11]3[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:10]=3[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.Br[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH2:20]([N:12]1[C:11]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:10]=2[N:9]=[C:8]1[C:7]1[C:2]([Cl:1])=[N:3][CH:4]=[CH:5][CH:6]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

参加物

反応物 2

HCID 7498Benzyl Bromide

HCID 717418032-(2-Chloropyridin-3-YL)-5,6-difluoro-1H-benzo[D]imidazole

生成物 1

HCID 866522871-Benzyl-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole

実験手順

The title compound was prepared in analogy to Example 1, intermediate a, from 2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole and bromomethyl-benzene (CAS Reg. No. 100-39-0). Colorless solid (52%). MS (Turbo Spray): m/z=356.3 (M+H).

出典と根拠

ORDレコード: ord-2de88540cdf44a35824de25ff5422075
出典データセット: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08309581B2

反応ノート

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