1-Bromopentane → 2-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-1-pentyl-1H-benzoimidazole

HRID 1875781ノート

反応式

HRID 1875781 の反応式
C1(COC2C(C3N(CC4C=CC(CCC(O)=O)=CC=4)C4C=C(F)C(F)=CC=4N=3)=CC=CN=2)CC1.[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[N:46]([CH2:47][CH:48]3CC[CH2:51][CH2:50][CH2:49]3)[C:45]3[CH:54]=[C:55]([F:59])[C:56]([F:58])=[CH:57][C:44]=3[N:43]=2)=[C:38]([O:60][CH2:61]C2C=CC=CC=2Cl)[CH:37]=1.BrCCCCC>>[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([C:42]2[N:46]([CH2:47][CH2:48][CH2:49][CH2:50][CH3:51])[C:45]3[CH:54]=[C:55]([F:59])[C:56]([F:58])=[CH:57][C:44]=3[N:43]=2)=[C:38]([O:60][CH3:61])[CH:37]=1

参加物

4

反応物 3

HCID 80571-BromopentaneHCID 510396793-{4-[2-(2-Cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acidHCID 582092722-[4-Chloro-2-(2-chloro-benzyloxy)-phenyl]-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole2 回

生成物 1

HCID 670498362-(4-Chloro-2-methoxy-phenyl)-5,6-difluoro-1-pentyl-1H-benzoimidazole

実験手順

The title compound was prepared in analogy to Example 19, intermediate b, from 2-(4-chloro-2-methoxy-phenyl)-5,6-difluoro-1H-benzoimidazole (Example 19, intermediate c) and 1-bromo-pentane (CAS Reg. No. 10-53-2). Brown powder (81%). MS (Turbo Spray): m/z=364.8 (M+H).

出典と根拠

ORDレコード
ord-f79882ec903747a0ad7a4955189bcdf2
出典データセット
uspto-grants-2012_11
特許番号
US08309581B2

反応ノート

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