1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 86646305、化合物

HRID 1876280ノート

反応式

HRID 1876280 の反応式
C1(P([N:15]=[N+:16]=[N-:17])(C2C=CC=CC=2)=O)C=CC=CC=1.N12CCCN=C1CCCCC2.[Cl:29][C:30]1[CH:39]=[C:38]2[C:33]([CH:34]=[CH:35][CH:36]=[C:37]2[CH2:40]O)=[CH:32][CH:31]=1>C1(C)C=CC=CC=1>[N:15]([CH2:40][C:37]1[C:38]2[C:33](=[CH:32][CH:31]=[C:30]([Cl:29])[CH:39]=2)[CH:34]=[CH:35][CH:36]=1)=[N+:16]=[N-:17]

参加物

5

反応物 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 199401P,P-Diphenylphosphinic azideHCID 68697042HCID 68697042、化合物

生成物 1

HCID 86646305HCID 86646305、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

1.52 ml of Diphenylphosphoryl azide and 1.10 ml of 1,8-diazabicyclo[5.4.0]undec-7-ene are added to 1.3 g of (7-Chloro-naphthalen-1-yl)-methanol in 18 ml of toluene. The mixture obtained is stirred at rt for 1 hour, washed with brine, the organic phase is dried and solvent is evaporated. The residue obtained is purified by flash chromatography on silica gel (eluent: cyclohexane/EtOAc 99/1) to yield the title compound.

後処理

  1. customThe mixture obtained
  2. washwashed with brine
  3. customthe organic phase is dried
  4. customsolvent is evaporated
  5. customThe residue obtained
  6. customis purified by flash chromatography on silica gel (eluent: cyclohexane/EtOAc 99/1)

出典と根拠

ORDレコード
ord-b045cfdf220a43718220c8c78611f6a2
出典データセット
uspto-grants-2012_11
特許番号
US08309596B2

反応ノート

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