Methylamine → 2-[(R)-2-(7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-N-methyl-acetamide
反応式
[CH:1]1([NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][C:22](O)=[O:23])[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:25][NH2:26]>>[CH:1]1([NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][C:22]([NH:26][CH3:25])=[O:23])[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1参加物
3
実験手順
The compound (97 mg, 0.28 mmol) prepared in Example 42 and methylamine instead of ethylamine were reacted according to the same procedure as Example 89 to give the title compound (34 mg, Yield 34%).
出典と根拠
- ORDレコード
- ord-924bf41e8cd844e29e900af2809974e3
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08309586B2
反応ノート
読み込み中…