Methyl 4-methyl-3-oxopentanoate → Methyl 2-isopropyl-5-[4-(trifluoromethyl)phenyl]-3-furoate

反応式

Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].[CH3:15][CH:16]([CH3:24])[C:17](=O)[CH2:18][C:19]([O:21][CH3:22])=[O:20]>>[CH:16]([C:17]1[O:4][C:3]([C:5]2[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=2)=[CH:2][C:18]=1[C:19]([O:21][CH3:22])=[O:20])([CH3:24])[CH3:15]

参加物

反応物 2

HCID 2759969Methyl 4-methyl-3-oxopentanoate

HCID 127899772-Chloro-1-[4-(trifluoromethyl)phenyl]ethan-1-one

生成物 1

HCID 23074492Methyl 2-isopropyl-5-[4-(trifluoromethyl)phenyl]-3-furoate収率 36.5%

実験手順

An operation similar to that in Example 1 (1) was performed using 2-chloro-4′-(trifluoromethyl)acetophenone (13.4 g) and methyl 4-methyl-3-oxopentanoate (7.2 g) to give the title compound (5.7 g, 36%) as an oil.

出典と根拠

ORDレコード: ord-391e3ec9bb9e4646a84e5e958134df10
出典データセット: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08309580B2

反応ノート

読み込み中…