5-(2,4-Difluorophenyl)-2-methyl-3-furaldehyde → Cyclohexyl[5-(2,4-difluorophenyl)-2-methyl-3-furyl]methanol

HRID 1876967

反応式

HRID 1876967 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[O:13][C:12]([CH3:14])=[C:11]([CH:15]=[O:16])[CH:10]=1.[CH:17]1([Mg]Br)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.O1CCCC1>>[CH:17]1([CH:15]([C:11]2[CH:10]=[C:9]([C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[F:1])[O:13][C:12]=2[CH3:14])[OH:16])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

参加物

3

反応物 2

HCID 835956455-(2,4-Difluorophenyl)-2-methyl-3-furaldehydeHCID 178420632HCID 178420632、化合物

生成物 1

HCID 68515112Cyclohexyl[5-(2,4-difluorophenyl)-2-methyl-3-furyl]methanol収率 76%

実験手順

An operation similar to that in Example 3 (2) was performed using 5-(2,4-difluorophenyl)-2-methyl-3-furaldehyde (2.4 g) and 1N cyclohexylmagnesium bromide-tetrahydrofuran solution (16.5 mL) to give the title compound (2.6 g, 76%) as a white crystal.

出典と根拠

ORDレコード
ord-11bb2b91221f40989159f4c2f696dd35
出典データセット
uspto-grants-2012_11
特許番号
US08309580B2

関連ノート

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