反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([CH3:13])=[C:10]([CH:14]=[O:15])[CH:9]=2)=[C:4]([CH3:16])[CH:3]=1.[CH:17]1([Mg]Br)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.O1CCCC1>>[CH:17]1([CH:14]([C:10]2[CH:9]=[C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[CH3:16])[O:12][C:11]=2[CH3:13])[OH:15])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1参加物
3
実験手順
An operation similar to that in Example 3 (2) was performed using 5-(4-fluoro-2-methylphenyl)-2-methyl-3-furaldehyde (2.6 g) and 1N cyclohexylmagnesium bromide-tetrahydrofuran solution (18 mL) to give the title compound (2.6 g, 72%) as an oil.
出典と根拠
- ORDレコード
- ord-16a088323c3a4b889b0e46625ec3144b
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08309580B2
関連ノート
読み込み中…