1-(Chloromethyl)-2-iodobenzene → 2-[(2-Iodobenzyl)thio]-cis-4,5-diphenyl-4,5-dihydro-1H-imidazole Hydrochloride

関与物質

反応手順

A mixture of intermediate 25 (200 mg, 0.786 mmol) and 2-iodobenzyl chloride (396 mg, 1.57 mmol) in abs. EtOH (2 mL) is heated at 95° C. for 24 h. The reaction mixture is cooled to RT, evaporated to dryness, and the residue suspended in Et2O. The insoluble material is filtered to give 270 mg of the product 222. 1H NMR (DMSO-d6) δ 11.43 (s, 2 H), 8.00 (d, 1 H), 7.82 (d, 1 H), 7.48 (t, 1 H), 7.30-7.00 (m, 7 H), 7.00-6.80 (m, 4 H), 5.82 (s, 2 H), 4.88 (s, 2 H); MS: m/z 471 (M++1).

情報源と証拠