1,2,3,4-Tetrahydroquinoline → HCID 59294482、化合物
反応式
[Cl:1][C:2]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:3]=1[O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:6]=1[C:7]([OH:9])=O.F[C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[NH:27][CH2:26][CH2:25][CH2:24]2.N1C2C(=CC=CC=2)CCC1>>[Cl:1][C:2]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:3]=1[O:4][C:5]1[CH:13]=[CH:12][C:11]([F:14])=[CH:10][C:6]=1[C:7]([N:27]1[C:28]2[C:23](=[CH:22][CH:21]=[CH:30][CH:29]=2)[CH2:24][CH2:25][CH2:26]1)=[O:9]参加物
4
実験手順
The title compound was prepared in analogy to Example 110, Step 2, replacing 2-(2,5-dichloro-phenoxy)-benzoic acid (Example 110, Step 1) with 2-(2,5-dichloro-phenoxy)-5-fluoro-benzoic acid and 6-fluoro-1,2,3,4-tetrahydro-quinoline with 1,2,3,4-tetrahydro-quinoline ([CAS RN 635-46-1]). MS (ISP): 416.1 [M+H]+.
出典と根拠
- ORDレコード
- ord-618c74402bee4ab684b4a7ba3f0377da
- 出典データセット
- uspto-grants-2012_11