Hydrogen Peroxide → 2-(2-acetylaminoethylamino)-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzamide

関与物質

反応手順

The process is carried out as in stage 3 of Example 3, but using 150 mg of 2-fluoro-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzonitrile, obtained according to stage 2 of Example 3, 148 mg of potassium carbonate and 810 mg of N-acetylethylenediamine in 1.2 ml of dimethyl sulphoxide. 0.4 ml of a 1M aqueous solution of sodium hydroxide, 0.4 ml of a 30% aqueous solution of hydrogen peroxide and 2 ml of ethanol are then added to the reaction medium. After treatment and purification as in stage 3 of Example 3, 72 mg of 2-(2-acetylaminoethylamino)-4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]benzamide are thus obtained in the form of a white solid, the characteristics of which are the following:

情報源と証拠