Hydrochloric Acid → 1-(Pyrimidin-4-yl)cyclopropan-1-amine hydrochloride
反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH:10]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)=[N:3][CH:2]=1.[ClH:18]>O1CCOCC1>[ClH:18].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH2:10])[CH2:9][CH2:8]2)=[N:3][CH:2]=1参加物
4
実験手順
A solution of tert-butyl 1-(pyrimidin-4-yl)cyclopropylcarbamate (0.100 g, 0.425 mmol, 1.0 eq), in 4.0 M HCl in 1,4-dioxane (4.0 ml) was stirred at r.t. for 5 hr. The reaction mixture was concentrated completely and the HCl salt was taken to next step.
後処理
- concentrationThe reaction mixture was concentrated completely
出典と根拠
- ORDレコード
- ord-42a12ac8705843e582ced20f95cc2b60
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08309558B2
反応ノート
読み込み中…