Potassium Carbonate → HCID 61699309、化合物
反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH:9]1([CH2:12][NH2:13])[CH2:11][CH2:10]1.C(=O)([O-])[O-].[K+].[K+].CC(N(C)C)=O>O>[Cl:8][C:4]1[N:3]=[C:2]([NH:13][CH2:12][CH:9]2[CH2:11][CH2:10]2)[CH:7]=[N:6][CH:5]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
A mixture of 2,6-dichloropyrazine (2.99 g), 1-cyclopropylmethanamine (2.14 g), potassium carbonate (4.14 g) and DMA (20 mL) was stirred at 80° C. for 23 hr. Water (15 mL) was added, and the mixture was extracted with ethyl acetate. The aqueous layer was extracted again with ethyl acetate. The combined organic layer was washed with water and saturated brine, dried over magnesium sulfate, and concentrated. This was used without purification for the next reaction.
後処理
- extractionthe mixture was extracted with ethyl acetate
- extractionThe aqueous layer was extracted again with ethyl acetate
- washThe combined organic layer was washed with water and saturated brine
- dry with materialdried over magnesium sulfate
- concentrationconcentrated
- customThis was used without purification for the next reaction
出典と根拠
- ORDレコード
- ord-1f4ce336b63849da85ccb19e39127bf8
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08314088B2
反応ノート
読み込み中…