m-Chlorophenylhydrazine hydrochloride → HCID 58345436、化合物

HRID 1877981ノート

反応式

HRID 1877981 の反応式
[CH2:1]([O:3][C:4](=[O:20])[C:5](=O)[CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH3:18])[CH:10]=1)=O)[CH3:2].Cl.[Cl:22][C:23]1[CH:24]=[C:25]([NH:29][NH2:30])[CH:26]=[CH:27][CH:28]=1>>[Cl:22][C:23]1[CH:24]=[C:25]([N:29]2[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH3:18])[CH:10]=3)=[CH:6][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:20])=[N:30]2)[CH:26]=[CH:27][CH:28]=1

参加物

3

反応物 2

HCID 75331m-Chlorophenylhydrazine hydrochlorideHCID 43186887Ethyl 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoate

生成物 1

HCID 58345436HCID 58345436、化合物収率 74%

実験手順

Starting from 1 g (3.57 mmol) of 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoic acid ethyl ester from example 12A and 868.8 mg (4.85 mmol) of 3-chlorophenylhydrazine hydrochloride, 1.03 g (2.7 mmol, 74% yield of theory) of product are obtained according to the method described in example 4A and after purification by preparative HPLC.

後処理

  1. customare obtained
  2. customafter purification by preparative HPLC

出典と根拠

ORDレコード
ord-8020358e08c04f1085f73136f4f21512
出典データセット
uspto-grants-2012_11
特許番号
US08314089B2

反応ノート

読み込み中…