Acetic Acid Mixture with Hydrobromic Acid → HCID 68486396、化合物
反応式
C([C:3]1[CH:4]=[CH:5][C:6]2[N:11](CC3C=CC(OC)=CC=3)[C:10](=[O:21])[O:9][C:8]([CH2:26][NH:27][C:28](=[O:36])[C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)([C:22]([F:25])([F:24])[F:23])[C:7]=2[CH:37]=1)#N.Br.[C:39]([OH:42])(=[O:41])C>O>[F:35][C:32]1[CH:31]=[CH:30][C:29]([C:28]([NH:27][CH2:26][C:8]2([C:22]([F:25])([F:24])[F:23])[C:7]3[CH:37]=[C:3]([C:39]([OH:42])=[O:41])[CH:4]=[CH:5][C:6]=3[NH:11][C:10](=[O:21])[O:9]2)=[O:36])=[CH:34][CH:33]=1参加物
4
実験手順
N-{[6-cyano-1-(4-methoxybenzyl)-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}-4-fluorobenzamide was dissolved in 25% hydrogen bromide-acetic acid (5 mL) and water (1 mL), and the solution was stirred overnight at 100° C. The temperature of the solution was brought to room temperature, and water was added thereto under stirring. After the solution was stirred at room temperature for 30 minutes, the resulting brown solid was dried under reduced pressure, whereby the objective compound (317 mg, 55%) was obtained as a brown solid.