Piperazin-4-ylacetophenone → 1-[(6-Chloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(4-acetylphenyl)piperazine

関与物質

役割	名称	HCID	仕込み量
反応物	Piperazin-4-ylacetophenone	HCID 97269	—
反応物	Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate	HCID 66918182	—
生成物	1-[(6-Chloro-2-methoxyquinoxalin-3-yl)aminocarbonyl]-4-(4-acetylphenyl)piperazine	HCID 66918014	85%

反応手順

Ethyl N-(6-chloro-2-methoxyquinoxalin-3-yl)carbamate and 1-(4-acetylphenyl)piperazine were reacted by the same way with the example 22 to obtain the titled compound (yield, 85%). 1H NMR (300 MHz, CDCl3): δ 2.54 (s, 3H), 3.50 (s, 4H), 3.80 (s, 3H), 4.14 (s, 4H), 6.89 (d, J=7.7 Hz, 2H), 7.44 (s, 1H), 7.66 (s, 1H), 7.79 (s, 1H), 7.79 (s, 1H), 7.91 (d, J=7.7 Hz, 2H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US08314100B2
出典データセット	uspto-grants-2012_11
ORD ID	ord-69760adc7a7f4eb1a0eb154c35da048a
出典メモ	uspto-grants-2012_11