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1-(3-Chlorophenyl)piperazine → 1-[(3-Methoxy-6-methylquinoxalin-2-yl)aminocarbonyl]-4-(3-chlorophenyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Chlorophenyl)piperazine | HCID 1355 | — |
| 反応物 | ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate | HCID 69243736 | — |
| 生成物 | 1-[(3-Methoxy-6-methylquinoxalin-2-yl)aminocarbonyl]-4-(3-chlorophenyl)piperazine | HCID 69244308 | 87% |
反応手順
Ethyl N-(3-methoxy-6-methylquinoxalin-2-yl)carbamate and 1-(3-chlorophenyl)piperazine were reacted by the same way with the example 127 to obtain the titled compound (yield, 87%). 1H NMR (300 MHz, CDCl3): δ 2.46 (s, 3H), 3.19-3.33 (m. 4H), 3.72-3.77 (m, 4H), 4.13 (s, 3H), 6.79-7.66 (m, 7H), 7.71 (d, J=8.6 Hz, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08314100B2 |
| 出典データセット | uspto-grants-2012_11 |
| ORD ID | ord-603f372f3992444dbd0b2e5896da81e9 |
| 出典メモ | uspto-grants-2012_11 |