Potassium Hydroxide → 5-[(Tert-butoxy)carbonyl]pyrazine-2-carboxylic acid

HRID 1878374ノート

反応式

HRID 1878374 の反応式
[C:1]([O:5][C:6]([C:8]1[N:9]=[CH:10][C:11]([C:14]([O:16]CC)=[O:15])=[N:12][CH:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+]>CO>[C:1]([O:5][C:6]([C:8]1[N:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 66878222HCID 66878222、化合物

生成物 1

HCID 668782615-[(Tert-butoxy)carbonyl]pyrazine-2-carboxylic acid収率 97.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a mixture of ethyl 5(tert-butoxycarbonyl)pyrazine-2-carboxylate (0.742 g, 2.78 mmol) and methanol (20 mL) was added potassium hydroxide (0.23 g, 4.1 mmol) in wafer (2 mL) and the reaction was stirred at room temperature overnight. The solvent was removed under vacuum and the residue was dissolved in wafer (5 mL) and acidified to pH 2 with 1M hydrochloric acid. The solid precipitate was collected by filtration to afford the title compound (0.61 g). MS (ESI) m/z 240.2 [M+H]+

後処理

  1. customThe solvent was removed under vacuum
  2. dissolutionthe residue was dissolved in wafer (5 mL)
  3. filtrationThe solid precipitate was collected by filtration

出典と根拠

ORDレコード
ord-d026c8b85c554e698687b34701d92487
出典データセット
uspto-grants-2012_11
特許番号
US08314091B2

反応ノート

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