Triethylamine → HCID 66878470、化合物

HRID 1878437ノート

反応式

HRID 1878437 の反応式
[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].C(N(CC)CC)C.[NH2:19][C:20]([CH:24]1[CH2:26][CH2:25]1)([CH3:23])[C:21]#[N:22]>ClCCl>[Cl:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6]([NH:19][C:20]([C:21]#[N:22])([CH:24]1[CH2:26][CH2:25]1)[CH3:23])=[O:7]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 27333243-(Chloromethyl)benzoyl chlorideHCID 37919192-amino-2-cyclopropylpropanenitrile

生成物 1

HCID 66878470HCID 66878470、化合物収率 60.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-(Chloromethyl)benzoyl chloride (9.08 mmol, 1.290 ml, 1.716 g) and triethylamine (27.2 mmol, 3.79 mL, 2.76 g) were stirred in dichloromethane (10 mL) at 0° C. 2-Amino-2-cyclopropylpropanenitrile (9.08 mmol, 1 g) was added dropwise and the reaction allowed to warm to room temperature and stir for 1 hour. The reaction mixture was washed with water and the organic phase concentrated under vacuum to afford the title compound (1.451 g). MS (ESI) m/z 263.1 [M+H]+

後処理

  1. washThe reaction mixture was washed with water
  2. concentrationthe organic phase concentrated under vacuum

出典と根拠

ORDレコード
ord-120790e8c52d46bca03a1e9ac3590c3b
出典データセット
uspto-grants-2012_11
特許番号
US08314091B2

反応ノート

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