6-(6-{[(1,1-Dimethylethoxy)carbonyl]amino}pyridin-2-yl)imidazo[1,2-a]pyridine-2-carboxylic acid → 6-(2-{[(1,1-Dimethylethoxy)carbonyl]amino}thiazol-4-yl)imidazo[1,2-a]pyridine-2-carboxylic acid
反応式
[CH3:1][C:2]([CH3:27])([O:4][C:5]([NH:7][C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:14]=[CH:15][C:16]3[N:17]([CH:19]=[C:20]([C:22]([O:24]CC)=[O:23])[N:21]=3)[CH:18]=2)[N:12]=1)=[O:6])[CH3:3].CC(C)(OC(NC1N=C(C2C=CC3N(C=C(C(O)=O)N=3)C=2)C=CC=1)=O)C>>[CH3:3][C:2]([CH3:27])([O:4][C:5]([NH:7][C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:14]=[CH:15][C:16]3[N:17]([CH:19]=[C:20]([C:22]([OH:24])=[O:23])[N:21]=3)[CH:18]=2)[N:12]=1)=[O:6])[CH3:1]参加物
3
反応物 2
生成物 1
実験手順
125 mg of ethyl 6-(2-{[(1,1-dimethylethoxy)carbonyl]amino}thiazol-4-yl)imidazo[1,2-a]pyridine-2-carboxylate are saponified under conditions similar to those described for the preparation of Intermediate 11 (step 11.3), to give 90 mg of 6-(2-{[(1,1-dimethylethoxy)carbonyl]amino}thiazol-4-yl)imidazo[1,2-a]pyridine-2-carboxylic acid in the form of a brown solid.
出典と根拠
- ORDレコード
- ord-dd036724a969486fb426ea96dd1bfbd5
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08314109B2
反応ノート
読み込み中…