Morpholine → 5-Chloro-7-morpholin-4-yl-3-phenyl-pyrazolo[1,5-a]pyrimidine

HRID 1878524ノート

反応式

HRID 1878524 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:4]2[N:3]=1.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[N:5]2[N:9]=[CH:10][C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:4]2[N:3]=1

参加物

4

反応物 2

HCID 8083MorpholineHCID 134659465,7-Dichloro-3-phenylpyrazolo[1,5-a]pyrimidine

生成物 1

HCID 585311525-Chloro-7-morpholin-4-yl-3-phenyl-pyrazolo[1,5-a]pyrimidine収率 82%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

There was dissolved, in 1,4-dioxane (2 mL), 5,7-dichloro-3-phenyl-pyrazolo-[1,5-a]pyrimidine (47.7 mg, 0.181 mM), then morpholine (31.6 μL, 0.362 mM) was added to the solution and the resulting mixture was stirred at room temperature for 30 minutes. The solvent was distilled off from this reaction mixture, the resulting residue was diluted with water and extracted with methylene chloride. The extracts thus obtained were combined, dried over anhydrous sodium sulfate, the solvent was then distilled off, and the resulting solid was washed with methanol to thus obtain the title compound (46.8 mg, yield: 82%).

後処理

  1. distillationThe solvent was distilled off from this reaction mixture
  2. additionthe resulting residue was diluted with water
  3. extractionextracted with methylene chloride
  4. customThe extracts thus obtained
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationthe solvent was then distilled off
  7. washthe resulting solid was washed with methanol

出典と根拠

ORDレコード
ord-367618bb276044539d6052317857ad8c
出典データセット
uspto-grants-2012_11
特許番号
US08314098B2

反応ノート

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