1-(2-Hydroxyethyl)piperazine → HCID 86659721、化合物

HRID 1878559ノート

反応式

HRID 1878559 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1.[OH:18][CH2:19][CH2:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:7]=[C:6]([N:24]2[CH2:25][CH2:26][N:21]([CH2:20][CH2:19][OH:18])[CH2:22][CH2:23]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1

参加物

3

反応物 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 49761343HCID 49761343、化合物

生成物 1

HCID 86659721HCID 86659721、化合物

実験手順

There was dissolved, in 1,4-dioxana (3 mL), 5,7-dichloro-2-phenyl-pyrazolo-[1,5-a]pyrimidine (50.4 mg, 0.191 mM), then 1-(2-hydroxyethyl)-piperazine (46 μL, 0.382 mM) was added to the solution and the mixture was stirred at room temperature for one hour. The solvent was distilled off from this reaction mixture and the resulting solid was washed with ethyl acetate to thus give the title compound in a quantitative yield.

後処理

  1. distillationThe solvent was distilled off from this reaction mixture
  2. washthe resulting solid was washed with ethyl acetate

出典と根拠

ORDレコード
ord-a872563a50704455ae358a0b497b1786
出典データセット
uspto-grants-2012_11
特許番号
US08314098B2

反応ノート

読み込み中…