Morpholine → HCID 86659725、化合物
反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([CH3:12])[CH:11]=[C:4]2[N:3]=1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[N:5]2[N:9]=[C:10]([CH3:12])[CH:11]=[C:4]2[N:3]=1参加物
4
実験手順
There was dissolved, in 1,4-dioxane (20 mL), 5,7-dichloro-2-methyl-pyrazolo-[1,5-a]pyrimidine (1.00 g, 4.95 mM), then morpholine (863 μL, 9.90 mM) was added to the solution and the mixture was stirred at room temperature for one hour. The solvent was then distilled off from this reaction mixture, the resulting residue was diluted with water and the mixture was extracted with methylene chloride. The resulting extracts were combined, dried over anhydrous sodium sulfate, the solvent was distilled off and the resulting solid was washed with methanol to thus give the title compound (927 mg, yield: 74%).