3-Acetylbenzaldehyde → HCID 70999655、化合物

HRID 1878587ノート

反応式

HRID 1878587 の反応式
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=O)(=[O:26])[CH3:25]>C(O)C>[C:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=[N:23][NH:22][C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[N:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=3)[CH:15]=[C:11]2[N:10]=1)(=[O:26])[CH3:25]

参加物

4

反応物 2

HCID 6434363-AcetylbenzaldehydeHCID 70867116HCID 70867116、化合物

生成物 1

HCID 70999655HCID 70999655、化合物収率 77.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.6 mg, 0.0983 mM), then 3-acetyl-benzaldehyde (14.6 mg, 0.0983 mM) was added to the solution and the mixture was stirred at room temperature overnight. The reaction liquid was filtered and then the resulting solid was washed with diethyl ether to thus give the title compound (33.6 mg, yield: 77%).

後処理

  1. customThe reaction liquid
  2. filtrationwas filtered
  3. washthe resulting solid was washed with diethyl ether

出典と根拠

ORDレコード
ord-dfb777223e874aff920bdea5ebf58b86
出典データセット
uspto-grants-2012_11
特許番号
US08314098B2

反応ノート

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