3-Isopropylbenzaldehyde → HCID 77933899、化合物

HRID 1878589ノート

反応式

HRID 1878589 の反応式
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=O)([CH3:26])[CH3:25]>C(O)C>[CH:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=[N:23][NH:22][C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[N:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=3)[CH:15]=[C:11]2[N:10]=1)([CH3:26])[CH3:25]

参加物

4

反応物 2

HCID 5206803-IsopropylbenzaldehydeHCID 70867116HCID 70867116、化合物

生成物 1

HCID 77933899HCID 77933899、化合物収率 26.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.1 mg, 0.0967 mM), then 3-isopropyl-benzaldehyde (14.3 mg, 0.0967 mM) was added to the solution and the mixture was stirred at room temperature overnight. The solvent was distilled off from this reaction liquid, the resulting residue was purified by the reversed phase HPLC and then subjected to a desalting treatment to thus give the title compound (11.3 mg, yield: 26%).

後処理

  1. distillationThe solvent was distilled off from this reaction liquid
  2. customthe resulting residue was purified by the reversed phase HPLC

出典と根拠

ORDレコード
ord-055a341b2fd14d15b0f9319f12ba2c77
出典データセット
uspto-grants-2012_11
特許番号
US08314098B2

反応ノート

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