Water → HCID 86632433、化合物

HRID 1878627ノート

反応式

HRID 1878627 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][CH2:10][OH:11])[CH:5]=[N:6][CH:7]=1.[CH3:12][S:13](Cl)(=[O:15])=[O:14].O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][CH2:10][O:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH:5]=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 242291823-(5-Bromopyridin-3-yl)prop-2-yn-1-ol2 回

生成物 1

HCID 86632433HCID 86632433、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-(5-Bromo-pyridin-3-yl)-prop-2-yn-1-ol (Intermediate 218) (1 eq, 2.41 mmol, 510 mg) is dissolved in DCM (5 ml), then TEA (1.5 eq, 3.61 mmol, 0.5 ml) and methanesulfonyl chloride (1.5 eq, 3.61 mmol, 0.28 ml) are added. The resulting mixture is stirred for 30 min at r.t. After addition of water the layers are separated, and the organic layer is dried with MgSO4, filtered, and concentrated under reduced pressure giving the title compound.

後処理

  1. customare separated
  2. dry with materialthe organic layer is dried with MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a4fd545fd7784c1ba9cd5b6db5c04699
出典データセット
uspto-grants-2012_11
特許番号
US08314112B2

反応ノート

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