Phosphorus oxychloride → 3-Chloro-5-phenyl-pyridazine-4-carbonitrile
反応式
O=[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:5]=[N:4][NH:3]1.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9]参加物
3
反応条件
- 温度
- 100 °C
実験手順
3-Oxo-5-phenyl-2,3-dihydro-pyridazine-4-carbonitrile (70 mg) was suspended in 1 mL phosphorous oxychloride and heated to 100° C. for 6 hours. The mixture was then cooled and poured onto ice. The resulting brown solid product was filtered and air dried and used in the next step without further purification.
後処理
- temperatureThe mixture was then cooled
- additionpoured onto ice
- filtrationThe resulting brown solid product was filtered
- customair dried
- customused in the next step without further purification
出典と根拠
- ORDレコード
- ord-800015b3b78a43a9babce63e6add21b0
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318467B2
反応ノート
読み込み中…